Ras GTPase activating protein



Ras GTPase activating protein (RasGAP) inactivates Ras from its active GTP-bound form to its GDP-bound form. It is part of the mitogenic signal transmission via its N-terminal SH2-SH3-SH2 domains. The images on the left and right correspond to one representative RasGAP structure, i.e. the human RasGAP SH3 domain (2gqi).

3D Structures of Ras GTPase activating protein
2gqi – hRasGAP SH3 domain – human – NMR

2jo5, 2j06 - hRasGAP SH3 domain

2gsb - hRasGAP SH2 domain – NMR

3bxj - hRasGAP SYNGAP fragment - rat